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Genetic counseling for psychiatric disorders.

D W Tsuang1, S V Faraone, M T Tsuang

  • 1Department of Psychiatry and Behavioral Sciences, University of Washington, Mental Illness Research Education and Clinical Center, VA Puget Sound Health Care System, 1160 South Columbian Way, Seattle, WA 98108, USA. dwt1@u. washington.edu

Current Psychiatry Reports
|March 29, 2001
PubMed
Summary

Human genetics advances offer new diagnostic tools for psychiatric disorders. However, genetic testing raises significant ethical, legal, and social concerns that require careful consideration.

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Area of Science:

  • Psychiatric Genetics
  • Human Genetics
  • Medical Genetics

Background:

  • Genetic research is rapidly identifying disease-causing mutations for over 450 disorders.
  • Advances in human genetics offer new opportunities for diagnosing heritable conditions.
  • The identification of susceptibility genes for psychiatric disorders is accelerating.

Purpose of the Study:

  • To review the principles of genetic counseling for psychiatric disorders.
  • To discuss the ethical, legal, and social implications of genetic testing for psychiatric conditions.
  • To provide a balanced perspective on the benefits and challenges of genetic advancements in psychiatry.

Main Methods:

  • Literature review of human genetics research.
  • Analysis of ethical, legal, and social implications (ELSI) of genetic testing.

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  • Discussion of genetic counseling principles in the context of psychiatric disorders.

    • Main Results:

    • Human genetics research is rapidly advancing, enabling the identification of genes linked to psychiatric disorders.
    • Genetic testing for psychiatric conditions is becoming increasingly feasible.
    • Significant ethical, legal, and social issues accompany the advent of genetic testing for psychiatric disorders.

    Conclusions:

    • The rapid progress in human genetics presents opportunities for psychiatric disorder diagnosis and research.
    • Genetic testing for psychiatric disorders necessitates careful consideration of ethical, legal, and social dimensions.
    • A cautious approach is warranted when integrating new genetic knowledge into medical practice, acknowledging potential unforeseen consequences.