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Related Experiment Videos

Extrapyramidal effects of neuroleptics.

A D Korczyn, G J Goldberg

    Journal of Neurology, Neurosurgery, and Psychiatry
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Long-term tranquilizer use in psychiatric patients frequently causes Parkinsonism. Orphenadrine effectively treated Parkinsonism in most patients, though some experienced worsened symptoms.

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    Area of Science:

    • Psychiatry
    • Neurology
    • Pharmacology

    Background:

    • Major tranquilizers are widely prescribed for psychiatric inpatients.
    • Long-term use of these medications can lead to extrapyramidal side effects, including Parkinsonism.
    • Parkinsonism is a significant concern impacting patient quality of life.

    Purpose of the Study:

    • To investigate the frequency of Parkinsonism in psychiatric inpatients on long-term tranquilizer therapy.
    • To evaluate the efficacy of orphenadrine in treating drug-induced Parkinsonism.
    • To explore factors influencing the development of Parkinsonism.

    Main Methods:

    • A double-blind crossover study was conducted on 66 psychiatric inpatients.
    • Patients had been on major tranquilizers for 4 to 16 years.

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  • Orphenadrine's effects on Parkinsonism signs were assessed and compared to placebo.

    • Main Results:

    • 61% of patients exhibited signs of Parkinsonism.
    • Parkinsonism was more frequent in female patients and those with organic brain pathology, though not statistically significant.
    • No correlation was found between tranquilizer duration and extrapyramidal effects.
    • 25 out of 40 patients with Parkinsonism showed improvement with orphenadrine.
    • 6 patients (15%) experienced more severe Parkinsonism symptoms with orphenadrine than placebo.

    Conclusions:

    • Long-term major tranquilizer use is associated with a high incidence of Parkinsonism in psychiatric inpatients.
    • Orphenadrine demonstrates therapeutic potential for managing drug-induced Parkinsonism.
    • Individual patient responses to orphenadrine vary, necessitating careful monitoring.