Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinoid signalling and skeletal development.

T M Underhill1, A V Sampaio, A D Weston

  • 1School of Dentistry, Faculty of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.

Novartis Foundation Symposium
|March 30, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methyltransferase G9A Regulates Osteogenesis via Twist Gene Repression.

Journal of dental research·2017
Same author

The transcriptional repressor HIC1 regulates intestinal immune homeostasis.

Mucosal immunology·2017
Same author

SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas.

Oncogene·2012
Same author

Mechanical force modulates scleraxis expression in bioartificial tendons.

Journal of musculoskeletal & neuronal interactions·2011
Same author

EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.

Oncogene·2010
Same author

Water pollution control.

Rhode Island medical journal·2010

Retinoic acid receptors (RARs) are crucial for skeletal development, regulating chondroblast differentiation and bone growth. Disrupting RAR signaling leads to significant skeletal malformations, highlighting its fundamental role in skeletogenesis.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Vitamin A metabolites, particularly retinoic acid (RA), are vital for development and homeostasis.
  • RA exerts its functions by interacting with nuclear hormone receptors known as RA receptors (RARs) to modulate gene transcription.
  • In developing mammalian limbs, RA influences the differentiation of various cell types, including chondrogenic cells.

Purpose of the Study:

  • To investigate the role of RAR-mediated signaling in chondroblast differentiation.
  • To understand the contribution of RA signaling to skeletal primordia growth, including appositional and longitudinal growth.
  • To elucidate the impact of RARs on skeletogenesis and skeletal development.

Main Methods:

  • Genetic analysis of RAR function in vivo.

Related Experiment Videos

  • Studies using transgenic mouse models with altered RAR activity in developing limbs.
  • Examination of chondrogenesis and skeletal development in response to RA signaling modulation.

    • Main Results:

    • Absence of RARs results in cartilage formation deficiencies and ectopic cartilage formation.
    • Altered RAR activity (dominant-negative or constitutively active) in transgenic mice leads to chondrogenesis defects and skeletal malformations.
    • RA signaling is essential for proper chondroblast differentiation and skeletal development.

    Conclusions:

    • RAR-mediated signaling plays a fundamental role in skeletogenesis.
    • Precise regulation of RAR activity is critical for normal skeletal development and preventing malformations.
    • RA signaling pathways are key targets for understanding and potentially treating skeletal disorders.