Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Determining changes in NIR absorption using a layered model of the human head.

J Steinbrink1, H Wabnitz, H Obrig

  • 1Physikalisch-Technische Bundesanstalt, Berlin, Germany.

Physics in Medicine and Biology
|March 30, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Physiological Mechanisms Drive Grey Matter Plasticity in Complex Versus Simple Sequence Learning.

Human brain mapping·2026
Same author

Depressive and anxiety symptoms in individuals with Long-COVID: Does social network matter? - Results of a German Long-COVID study.

Journal of affective disorders·2026
Same author

Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter.

bioRxiv : the preprint server for biology·2025
Same author

Excitability Modulations of Somatosensory Perception Do Not Depend on Feedforward Neuronal Population Spikes.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Blood Flow Velocity Analysis in Cerebral Perforating Arteries on 7T 2D Phase Contrast MRI with an Open-Source Software Tool (SELMA).

Neuroinformatics·2025
Same author

Linking brain-heart interactions to emotional arousal in immersive virtual reality.

Psychophysiology·2024

This study introduces a novel theoretical approach to measure light absorption changes in layered tissues using photon time-of-flight distributions. The method enables depth-resolved absorption measurements, validated in phantoms and human head studies for potential bedside monitoring applications.

Area of Science:

  • Biomedical Optics
  • Photonics
  • Medical Imaging

Background:

  • Accurate measurement of tissue optical properties is crucial for understanding physiological processes.
  • Non-invasive techniques are needed for real-time monitoring of tissue function.
  • Depth-resolved absorption changes provide insights into localized physiological events.

Purpose of the Study:

  • To develop and validate a theoretical framework for determining absorption changes in layered biological tissues.
  • To assess the depth-resolution capabilities of a single-distance, time-domain method.
  • To demonstrate the applicability of the method for in vivo human measurements and bedside monitoring.

Main Methods:

  • A theoretical approach based on photon time-of-flight distributions was developed.

Related Experiment Videos

  • Calculations included changes in spatial profiles of time-integrated intensity and mean time of flight.
  • The method was tested on a layered phantom and applied to in vivo human head measurements.

    • Main Results:

    • The single-distance, time-domain method demonstrated capability for depth-resolved absorption change determination.
    • In vivo measurements during motor stimulation and Valsalva maneuver showed successful application.
    • A compact time-domain setup suitable for bedside monitoring was introduced.

    Conclusions:

    • The presented theoretical approach effectively determines absorption changes in layered structures.
    • The time-domain method offers depth resolution for non-invasive tissue monitoring.
    • The developed experimental setup facilitates practical bedside applications in clinical settings.