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Updated: Jul 30, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity
R L Beard1, E S Klein, A M Standeven
1Department of Chemistry, Retinoid Research, Allergan Incorporated, Irvine, CA 92623-9534, USA.
Abstract:
Retinoids are natural and synthetic analogues of the hormone retinoic acid. Systemic retinoid agonist therapy is usually associated with toxic side effects, such as mucocutaneous toxicity, which may be alleviated by the use of topical retinoid antagonists. We report the synthesis and biological activity of a new series of potent, RAR-specific antagonists substituted with phenylcyclohexene and phenylcyclohexadiene groups.
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