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Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the
S K Sharma1, A T Morrissey, G G Miller
1Department of Chemistry, University of Alberta, Edmonton, Canada.
Bioorganic & Medicinal Chemistry Letters
|March 30, 2001
Abstract:
The design and synthesis of the lipophilic (9) and fluorescent (10) conjugates of a structural analogue of distamycin and their in vitro cellular localization studies are reported. Confocal laser scanning microscopy (CLSM) indicates that 10 rapidly enters human ovarian adenocarcinoma (SKOV-3) cells with principal uptake in mitochondria and uniform cytoplasmic distribution.