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NO-independent stimulators of soluble guanylate cyclase
A Straub1, J P Stasch, C Alonso-Alija
1Institute of Medicinal Chemistry, Pharma Research Centre, Bayer AG, Wuppertal, FRG. alexander.straub.as@bayer-ag.de
Bioorganic & Medicinal Chemistry Letters
|March 30, 2001
Abstract:
SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.