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A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties
U Laban1, D Kurrasch-Orbaugh, D Marona-Lewicka
1Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, USA.
Bioorganic & Medicinal Chemistry Letters
|March 30, 2001
Abstract:
Synthesis and biological evaluation of a novel fluorinated tryptamine analogue are described. This new compound 1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine (2) was found to be a potent serotonin 5-HT1A agonist.