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Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues
G Kokotos1, V Constantinou-Kokotou, J M Padrón
1Department of Chemistry, University of Athens, Greece. gkokotos@cc.uoa.gr
Bioorganic & Medicinal Chemistry Letters
|March 30, 2001
Abstract:
Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.