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Related Experiment Videos

Involvement of apolipoprotein E in herpes simplex encephalitis.

J A Nicoll1, L Martin, J Stewart

  • 1Department of Neuropathology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, UK.

Neuroreport
|March 30, 2001
PubMed
Summary

Apolipoprotein E (APOE) is involved in brain injury response during herpes simplex encephalitis (HSE). However, APOE genotype does not affect HSE risk or mortality outcomes.

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Area of Science:

  • Neuroscience
  • Genetics
  • Infectious Diseases

Background:

  • Apolipoprotein E (APOE) polymorphism is linked to Alzheimer's disease (AD) risk and outcomes after brain injury.
  • APOE's role in herpes simplex encephalitis (HSE) risk and prognosis is not well understood.

Purpose of the Study:

  • To investigate if APOE genotype influences HSE risk.
  • To determine if apoE is involved in the brain's response to HSE.
  • To assess if APOE genotype affects HSE patient outcomes.

Main Methods:

  • Analysis of APOE genotypes in HSE cases (n=57) and controls (n=41).
  • Examination of apoE immunoreactivity in brain tissue affected by HSE.
  • Comparison of APOE genotypes between HSE survivors and non-survivors.

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Main Results:

  • Increased apoE immunoreactivity was observed in brain areas damaged by HSE.
  • APOE genotype frequencies did not differ between HSE cases and controls.
  • APOE genotypes were similar in HSE survivors and those who died.

Conclusions:

  • ApoE participates in the brain's response to HSE-related damage, similar to other brain injuries.
  • APOE genotype does not appear to influence the risk of developing HSE.
  • APOE genotype does not significantly impact mortality following HSE.