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Complications associated with intraperitoneal chemotherapy catheters
S Makhija1, M Leitao, P Sabbatini
1Department of Gynecologic Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Gynecologic Oncology
|March 30, 2001
Summary
Subcutaneous intraperitoneal (ip) catheters for ovarian cancer chemotherapy show a 10% complication rate, with infection and obstruction being most common. Avoiding bowel surgery and using laparoscopy for placement may reduce these risks.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Devices
Background:
- Intraperitoneal (ip) chemotherapy is a treatment for advanced ovarian cancer.
- Subcutaneous ip catheters facilitate ip chemotherapy delivery.
- Complication rates associated with these catheters require evaluation.
Purpose of the Study:
- To determine the complication rate of subcutaneous ip catheters in advanced ovarian cancer patients.
- To identify predisposing risk factors for these complications.
Main Methods:
- Retrospective chart review of 301 patients receiving ip chemotherapy via subcutaneous Bardport catheters.
- Data collected from December 1989 to May 1997 at Memorial Sloan--Kettering Cancer Center.
- Analysis of complication types, placement methods, and chemotherapy regimens.
Main Results:
- A 10% complication rate (30/301 patients) was observed, including inflow obstruction (6.3%) and infection (3.6%).
- Catheter malfunction or infection led to chemotherapy cessation in 7% of patients.
- Catheter placement during laparotomy was associated with higher complication rates compared to laparoscopy or separate procedures.
Conclusions:
- Subcutaneous ip catheters have a lower complication rate than previously reported.
- Avoiding ip catheter insertion during bowel surgery and opting for laparoscopic placement may decrease complications.
- These findings support optimizing surgical techniques for ip catheter placement.