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New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species
K M Meragelman1, T C McKee, M R Boyd
1Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-FCRDC, Frederick, MD 21702, USA.
Journal of Natural Products
|March 30, 2001
Abstract:
Three new isomalabaricane triterpenes, 29-hydroxystelliferin E (1), 29-hydroxystelliferin A (2), and stelliferin G (3), together with the known triterpene 3-epi-29-hydroxystelliferin E (4), were isolated from the organic extract of the sponge Jaspis sp. collected in the South Pacific. All the compounds isolated showed antiproliferative activity against melanoma cells (MALME-3M).