Related Experiment Videos
Synthesis and study of some 4-aza and 17a-azasteroidal isoxazoles
R Gupta1, D Pathak, D P Jindal
1University Institute of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India.
European Journal of Medicinal Chemistry
|March 30, 2001
Abstract:
4-Aza-5 alpha-androstano[2,3-d]isoxazole 4 and 17a-aza-D-homo-5-androsteno[17,16-c]isoxazole 7 have been prepared by treating alpha,beta-unsaturated-beta-chloroaldehydes 3 and 6 [1, 2] with hydroxylamine hydrochloride in pyridine. [16,17-d]Isoxazole derivatives 4 and 8 were found to be unstable in most of the organic solvents. beta-Cyanolactam derivatives 5 and 9 have also been prepared in both the series.