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Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone

J U Wurthner1, D B Frank, A Felici

  • 1Laboratory of Cell Regulation and Carcinogenesis and Laboratory of Receptor Biology and Gene Expression, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

The Journal of Biological Chemistry
|March 30, 2001
PubMed
Summary

Heat shock protein TRAP1 binds inactive TGF-beta receptors and Smad4, acting as a chaperone to facilitate Smad4 transfer and regulate transforming growth factor-beta signaling pathways.

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