Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nephron functional heterogeneity in the postobstructive kidney.

D R Wilson

    Kidney International
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Using systems mapping to understand the constraints and enablers of solutions to plastic pollution.

    Journal of environmental management·2024
    Same author

    Enhanced case management can be delivered for patients with EVD in Africa: Experience from a UK military Ebola treatment centre in Sierra Leone.

    The Journal of infection·2017
    Same author

    Asymptomatic group A Streptococcal throat carriage in Royal Marines recruits and Young Officers.

    The Journal of infection·2017
    Same author

    Simultaneous saccharification and fermentation of steam exploded duckweed: Improvement of the ethanol yield by increasing yeast titre.

    Bioresource technology·2015
    Same author

    Response to Letter to the Editor: 'Is subchondral bone mineral density associated with nocturnal pain in knee osteoarthritis patients?'.

    Osteoarthritis and cartilage·2015
    Same author

    Commentary: The use of creatine supplements in the military.

    Journal of the Royal Army Medical Corps·2015
    Same journal

    KDIGO Life Cycle of Guideline Development Series Part 6: Bridging the Gap between Guidelines and Clinical Practice: The KDIGO Approach to Global Implementation and Education in Nephrology.

    Kidney international·2026
    Same journal

    KDIGO Life Cycle of Guideline Development Series Part 5: Guideline updates and a living model for the future.

    Kidney international·2026
    Same journal

    Crystal-Storing Histiocytosis Causing Severe AKI.

    Kidney international·2026
    Same journal

    Peritoneal dialysis in a patient with extensive burn scarring.

    Kidney international·2026
    Same journal

    COPA syndrome unmasked by anti-neutrophil cytoplasmic antibody-positive immune-complex nephritis.

    Kidney international·2026
    Same journal

    Monitoring anti-nephrin antibodies in the management of recurrent diffuse podocytopathy.

    Kidney international·2026
    See all related articles

    After acute kidney obstruction relief, nephron filtration rates did not significantly redistribute. Chronic obstruction, however, altered nephron filtration, impacting kidney function and water conservation.

    Area of Science:

    • Nephrology
    • Renal Physiology
    • Urology

    Background:

    • Kidney obstruction can lead to significant physiological changes.
    • Understanding nephron filtration distribution is crucial for diagnosing renal dysfunction.
    • Postobstructive diuresis is a complex phenomenon requiring further investigation.

    Purpose of the Study:

    • To determine the superficial to juxtamedullary nephron filtration rate ratio (S/J ratio) after acute and chronic kidney obstruction.
    • To investigate the role of nephron filtration redistribution in postobstructive diuresis.
    • To explore the implications of altered nephron function in chronic hydronephrosis.

    Main Methods:

    • Utilized 14C-ferrocyanide injection and microdissection (modified Hanssen's technique) to assess nephron glomerular filtration rate (GFR).

    Related Experiment Videos

  • Performed standard clearance determinations for comprehensive renal function assessment.
  • Compared S/J ratios in normal kidneys versus those with acute and chronic obstruction.

    • Main Results:

    • Normal kidneys exhibited an S/J ratio of 0.73 ± 0.03.
    • Following acute obstruction relief, nephron GFR was unmeasurable in some nephrons, but the S/J ratio remained similar to controls (0.67 ± 0.07).
    • After chronic obstruction relief, the S/J ratio increased to 0.95 ± 0.11, with a loss of distinction between superficial and deep nephron GFR in most kidneys.

    Conclusions:

    • Nephron filtration redistribution is not a primary factor in acute postobstructive diuresis.
    • Altered nephron filtration after chronic obstruction may result from severe renal medulla damage.
    • This redistribution may contribute to the impaired salt and water conservation in chronically hydronephrotic kidneys.