Related Experiment Video

Updated: Aug 10, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

Pathology of the liver in Reye's syndrome

D J Svoboda, J K Reddy

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |May 1, 1975
    PubMed

    Insights

    Reye

    Area of Science:

    • Hepatology
    • Pediatric Pathology
    • Cell Biology

    Background:

    • Reye's syndrome is a severe condition affecting children and adolescents.
    • Previous studies suggested significant mitochondrial alterations in Reye's syndrome.
    • Liver cell damage, including inflammation and necrosis, is a key feature.

    Purpose of the Study:

    • To investigate the ultrastructural changes in liver cells of patients with Reye's syndrome.
    • To correlate light and electron microscopy findings with patient outcomes (fatal vs. survival).

    Main Methods:

    • Light microscopy of liver tissue.
    • Electron microscopy (ultrastructure) of liver cells.
    • Comparison of findings between fatal and surviving patients.

    Main Results:

    • Prominent inflammation and necrosis observed in fatal cases via light microscopy.
    • Minimal mitochondrial structural alterations noted on electron microscopy, contrary to prior reports.
    • Microbodies showed unusual noncrystalline cores; no increase in microbody number.
    • No distinct ultrastructural differences identified between fatal and surviving patients.

    Conclusions:

    • Mitochondrial dysfunction may occur in Reye's syndrome pathogenesis but is not always evident ultrastructurally.
    • Liver cell necrosis and inflammation are more pronounced in fatal Reye's syndrome cases.
    • Electron microscopy did not reveal specific ultrastructural markers to differentiate outcomes.

    More Related Videos

    Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen09:44

    Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

    Published on: November 27, 2019

    Cell Type-specific Gene Expression Profiling in the Mouse Liver10:06

    Cell Type-specific Gene Expression Profiling in the Mouse Liver

    Published on: September 17, 2019

    Related Concept Videos

    Liver Regeneration01:24

    Liver Regeneration

    The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
    Cells of Liver
    The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
    Diseases of the Liver and Gallbladder01:26

    Diseases of the Liver and Gallbladder

    Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
    Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
    Encephalitis ll: Pathophysiology01:26

    Encephalitis ll: Pathophysiology

    Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
    Cirrhosis I: Introduction01:23

    Cirrhosis I: Introduction

    Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
    Cirrhosis II: Pathophysiology01:24

    Cirrhosis II: Pathophysiology

    Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
    Hepatic Encephalopathy01:29

    Hepatic Encephalopathy

    DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...