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Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

V Martel1, C Racaud-Sultan, S Dupe

  • 1LEDAC, UMR CNRS/UJF 5538, Institut Albert Bonniot, Faculté de Médecine de Grenoble, 38706 La Tronche Cedex, France.

The Journal of Biological Chemistry
|March 30, 2001
PubMed
Summary

Phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) binding to talin activates its integrin-binding activity, crucial for focal adhesion assembly. This lipid signaling regulates talin

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