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Related Experiment Videos

Computerised advice on drug dosage to improve prescribing practice.

R T Walton1, E Harvey, S Dovey

  • 1University of Oxford Department of Public Health and Primary Care, Imperial Cancer Research Fund General Practice Research Group, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. rwalton@ermine.ox.ac.uk

The Cochrane Database of Systematic Reviews
|May 2, 2001
PubMed
Summary

Computer-assisted drug dosage systems significantly reduce time to therapeutic control, toxic drug levels, adverse reactions, and hospital stay. This review supports computer assistance for optimizing drug dosing in patient care.

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Area of Science:

  • Clinical Pharmacology
  • Health Informatics
  • Evidence-Based Medicine

Background:

  • Maintaining therapeutic drug concentrations is challenging.
  • Computer systems can aid physicians in optimizing drug dosages.
  • Computer-assisted drug dosing has the potential for significant patient health benefits.

Purpose of the Study:

  • To evaluate the efficacy of computer support systems in drug dosage management.
  • To determine if computer-assisted drug dosing improves patient outcomes.
  • To inform the broader availability of these technologies.

Main Methods:

  • Systematic review of randomized trials, interrupted time series, and controlled before-and-after studies.
  • Searched multiple databases (Cochrane, MEDLINE, EMBASE) and hand-searched journals.

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  • Included studies focused on health professionals managing drug dosages and patient health outcomes.

    • Main Results:

    • Fifteen trials involving 1229 patients were analyzed.
    • Computer support significantly reduced time to therapeutic control (SMD -0.44), toxic drug levels (RD -0.12), adverse reactions (RD -0.06), and hospital stay (SMD -0.32).
    • A trend towards higher drug doses was observed but not statistically significant.

    Conclusions:

    • Evidence supports the use of computer assistance for drug dosage determination.
    • Further clinical trials are needed to confirm benefits in general practice settings.
    • Computerized drug dosing systems show promise for improving patient safety and care efficiency.