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Related Experiment Videos

Familial hemiplegic migraine.

G G Glista, J F Mellinger, E D Rooke

    Mayo Clinic Proceedings
    |June 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study details a family with ten members experiencing hemiplegic migraine, a neurological disorder. Attacks were consistent within the family, with some triggered by head trauma, and one case resulted in permanent neurological deficit.

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    Area of Science:

    • Neurology
    • Genetics

    Background:

    • Hemiplegic migraine is a rare subtype of migraine with aura, characterized by neurological symptoms mimicking stroke.
    • Familial hemiplegic migraine (FHM) suggests a genetic component in migraine pathophysiology.

    Purpose of the Study:

    • To describe the clinical presentation and familial occurrence of hemiplegic migraine.
    • To investigate potential triggers and outcomes in affected family members.

    Main Methods:

    • Case series describing ten affected members of a single family.
    • Clinical observation of migraine attack characteristics and triggers.
    • Assessment of neurological outcomes.

    Main Results:

    • Ten family members presented with hemiplegic migraine.

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  • Migraine attacks exhibited stereotyped patterns within the family.
  • Three members experienced attacks following minor head trauma.
  • One patient developed a permanent neurological deficit.

    • Conclusions:

    • Hemiplegic migraine can manifest with significant familial aggregation.
    • Head trauma may act as a trigger in susceptible individuals.
    • The potential for permanent neurological sequelae warrants further investigation and management strategies.