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Updated: Aug 11, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Fatal Pneumocystis carinii pneumonia in HIV-seropositive infants in Harare, Zimbabwe
K J Nathoo1, M Gondo, L Gwanzura
1Department of Paediatrics and Child Health, University of Zimbabwe Medical School, P.O. Box A178, Avondale, Harare, Zimbabwe. knathoo@healthnet.zw
Abstract:
Lung biopsies taken post mortem from 24 HIV-seropositive children who died of pneumonia in Harare Hospital (Zimbabwe) during 1995 were examined for pathogens using histology, culture, microscopy and polymerase chain reaction (PCR). Pneumocystis carinii was detected in 16 (67%) children, in 5 of whom bacterial pathogens were also detected. There were 2 cases of cytomegalovirus infection. On the basis of histology and PCR, none of the children had tuberculosis. These data add to the evidence that P. carinii pneumonia may be a significant cause of death in HIV-infected children in southern Africa. Policies on treatment for severe pneumonia, and on prophylaxis for children born to HIV-seropositive mothers need to be re-examined.
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