Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epinephrine, norepinephrine and dopamine infusions decrease propofol concentrations during continuous propofol

J A Myburgh1, R N Upton, C Grant

  • 1Department of Anaesthesia and Intensive Care, University of Adelaide, Royal Adelaide Hospital, Australia. j.myburgh@unsw.edu.au

Intensive Care Medicine
|March 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel entorhinal projection to the rat dentate gyrus: direct innervation of proximal dendrites and cell bodies of granule cells and GABAergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·1996
Same author

Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.

Gastroenterology·1996
Same author

Mutational analysis and secondary structure model of the RNP1-like sequence motif of transcription termination factor Rho.

Journal of molecular biology·1996
Same author

Residues in the RNP1-like sequence motif of Rho protein are involved in RNA-binding affinity and discrimination.

Journal of molecular biology·1996
Same author

Effects of continuous low-dose-rate brachytherapy on the rectum of the rat.

Radiation research·1996
Same author

Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice.

The American journal of tropical medicine and hygiene·1996

Catecholamine infusions like epinephrine, norepinephrine, and dopamine transiently reversed propofol anesthesia by increasing cardiac output, leading to lower propofol blood concentrations. This has implications for managing anesthesia in hyperdynamic states.

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Cardiovascular Physiology

Background:

  • Propofol is a widely used intravenous anesthetic agent.
  • Catecholamines are commonly used to manage hemodynamic stability during anesthesia.
  • The interaction between catecholamines and propofol pharmacokinetics is not fully understood.

Purpose of the Study:

  • To investigate the impact of exogenous epinephrine, norepinephrine, and dopamine infusions on propofol concentrations in arterial and brain blood during steady-state anesthesia.
  • To elucidate the pharmacokinetic changes in propofol influenced by catecholamine-induced circulatory alterations.

Main Methods:

  • A prospective, randomized animal study was conducted in five adult female merino sheep.
  • Sheep received a continuous infusion of propofol for anesthesia.

Related Experiment Videos

  • Ramped infusions of epinephrine, norepinephrine, and dopamine were administered, followed by washout periods.

    • Main Results:

    • Epinephrine, norepinephrine, and dopamine significantly increased cardiac output in a dose-dependent manner.
    • All tested catecholamines reduced arterial and sagittal sinus propofol concentrations, with parallel decreases in blood leaving the brain.
    • Lower propofol concentrations correlated with increased cardiac output and were associated with emergence from anesthesia.

    Conclusions:

    • Catecholamine administration induced circulatory changes that effectively reversed propofol-induced anesthesia.
    • These findings suggest that propofol's efficacy may be diminished in hyperdynamic conditions.
    • Clinical implications exist for propofol use in patients with pathological hyperdynamic states or those receiving exogenous catecholamine infusions.