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Acute hepatic steatosis complicating massive insulin overdose and excessive glucose administration
P Jolliet1, X Leverve, C Pichard
1Medical ICU Division, University Hospital, Geneva, Switzerland. jolliet@cmu.unige.ch
Objective:
To describe a case of acute hepatic steatosis due to excessive administration of glucose in the setting of massive insulin overdose, a complication which is rapidly and completely reversible if glucose infusion is rapidly tapered.
Design:
Case report, clinical.
Setting:
Intensive care unit, university hospital.
Patient:
A single patient admitted to the ICU.
Intervention:
Intravenous glucose after insulin overdose.
Measurements And Main Results:
On the 3rd day, increases in transaminase (ASAT 420 IU/l, ALAT 610 IU/l), bilirubin (147 mmol/l) and lactate (6.8 mmol/l), a decrease in arterial pH (7.32) and slightly increased liver size on ultrasound examination suggested acute hepatic steatosis. Clinical and laboratory abnormalities resolved rapidly after discontinuation of excessive glucose infusions (1,400 g/day for 3 days).
Conclusions:
Very large amounts of glucose after massive insulin overdose are potentially dangerous. Even though the fear of hypoglycemia-induced neurologic damage should be a constant preoccupation in this situation, glucose administration should be titrated on closely monitored blood glucose levels.