Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Transitional pre-B-cell ALL].

C Yun1, A Kamitamari, M Okada

  • 1Department of Pediatrics, Nagasaki University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atezolizumab plus bevacizumab in advanced Merkel cell carcinoma: A prospective study.

Oral oncology·2024
Same author

Micromagnetic simulation of microstructure effect for binary-main-phase Nd-Ce-Fe-B magnets.

Journal of physics. Condensed matter : an Institute of Physics journal·2021
Same author

Prospective multinational serosurveillance study of Bordetella pertussis infection among 10- to 18-year-old Asian children and adolescents.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same author

Adults with intellectual disabilities in China: comorbid psychiatric disorder and its association with health service utilisation.

Journal of intellectual disability research : JIDR·2017
Same author

Microsomal Triacylglycerol Synthesis and Diacylglycerol Concentration in the Liver of Rats Fed with Soybean and Egg Yolk Phospholipids.

Bioscience, biotechnology, and biochemistry·2016
Same author

Assessment of selenium nutritional status of school-age children from rural areas of China in 2002 and 2012.

European journal of clinical nutrition·2015
Same journal

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
Same journal

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
Same journal

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
Same journal

[Recent advances in pathogenesis, diagnosis, and therapeutic strategies for POEMS syndrome].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
Same journal

[Recent advances in management of systemic AL amyloidosis].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
Same journal

[Treatment strategies for relapsed or refractory multiple myeloma: proposals for optimal treatment sequencing].

[Rinsho ketsueki] The Japanese journal of clinical hematology·2026
See all related articles

This study reports a rare case of acute lymphoblastic leukemia (ALL) in an infant, specifically transitional pre-B-cell ALL (TPB-ALL). Accurate immunophenotypic diagnosis is crucial for managing this infrequent leukemia subtype.

Area of Science:

  • Pediatric Hematology Oncology
  • Immunology
  • Cell Biology

Background:

  • Acute lymphoblastic leukemia (ALL) is a significant pediatric malignancy.
  • Transitional pre-B-cell ALL (TPB-ALL) is an uncommon subtype with uncertain incidence and clinical presentation.
  • Early diagnosis and effective management are critical for improving outcomes in pediatric ALL.

Observation:

  • An 18-month-old girl presented with fever and pancytopenia.
  • Bone marrow examination revealed blasts with cleaved nuclei.
  • Leukemic cells were negative for peroxidase, expressed CD10, CD19, CD34, and surface immunoglobulin mu (sIg mu), but lacked sIg kappa and lambda.

Findings:

  • The immunophenotype identified the leukemic cells as transitional pre-B-cells (TPBs).

Related Experiment Videos

  • This diagnosis corresponds to a minor subpopulation of B cells.
  • The case highlights the infrequent occurrence of TPB-ALL.

    • Implications:

    • Extensive immunophenotypic studies are essential for diagnosing rare ALL subtypes like TPB-ALL.
    • Understanding the clinical picture of TPB-ALL is necessary for developing targeted therapies.
    • Accurate diagnosis facilitates effective management and improves patient outcomes.