Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treatment-resistant bipolar disorder.

M J Gitlin1

  • 1Department of Psychiatry, UCLA School of Medicine, USA.

Bulletin of the Menninger Clinic
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Newer pharmacotherapies for bipolar disorder show promise, particularly anticonvulsants like lamotrigine for depression. Research is ongoing for other treatments, including novel antipsychotics and adjunctive strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature.

The American journal of psychiatry·2001
Same author

Efficacy and response time to sertraline versus fluoxetine in the treatment of unipolar major depressive disorder.

The Journal of clinical psychiatry·2001
Same author

Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: relation to side effects, psychosocial function and depression.

Psychopharmacology·2000
Same author

Bupropion-tranylcypromine combination for treatment-refractory depression.

The Journal of clinical psychiatry·2000
Same author

Gender and bipolar illness.

The Journal of clinical psychiatry·2000
Same journal

Identifying factors associated with sleep disturbance among adults seeking outpatient psychiatric services for anxiety and related disorders.

Bulletin of the Menninger Clinic·2026
Same journal

From unplanned attempts to planned deaths: A comparative analysis of suicidal behavior in rural Türkiye.

Bulletin of the Menninger Clinic·2026
Same journal

Toward a double bind theory of borderline personality disorder.

Bulletin of the Menninger Clinic·2026
Same journal

An evaluation of factor structure, measurement invariance, and psychometric properties of the Psychache Scale.

Bulletin of the Menninger Clinic·2026
Same journal

Psychiatric and behavioral symptoms after pediatric herpes simplex virus type 1 encephalitis: An exploratory case series.

Bulletin of the Menninger Clinic·2026
Same journal

Object relations moderate the relationship between emotion regulation and quality of life among psychiatric inpatients: A brief report.

Bulletin of the Menninger Clinic·2026
See all related articles

Area of Science:

  • Pharmacology
  • Psychiatry
  • Neurology

Background:

  • The pharmacotherapy landscape for bipolar disorder has expanded significantly.
  • Evidence for many newer treatments is primarily based on case reports and series.
  • Anticonvulsants and novel antipsychotics represent promising avenues for treatment.

Purpose of the Study:

  • To review recent advancements in pharmacotherapies for bipolar disorder.
  • To highlight the efficacy and limitations of emerging treatments.
  • To discuss alternative and adjunctive strategies for treatment-resistant cases.

Main Methods:

  • Literature review of recent studies on bipolar disorder pharmacotherapy.
  • Analysis of evidence quality for novel treatments.

Related Experiment Videos

  • Discussion of treatment combinations and resistant cases.

    • Main Results:

    • Lamotrigine demonstrates efficacy in bipolar depression; gabapentin requires further controlled studies.
    • Topiramate, an anticonvulsant, is noted for weight loss effects.
    • Novel antipsychotics are effective for acute mania, but long-term mood-stabilizing effects require more research.
    • Combination therapies require careful consideration of pharmacokinetic interactions.
    • Other options for treatment-resistant bipolar disorder include thyroid hormones, calcium channel blockers, electroconvulsive therapy, and omega-3 fatty acids.

    Conclusions:

    • Recent pharmacotherapies offer new hope for bipolar disorder management, with anticonvulsants and novel antipsychotics showing particular potential.
    • Further controlled studies are needed to establish the efficacy of many newer agents.
    • Adjunctive psychosocial strategies are an active area of investigation for comprehensive bipolar disorder treatment.