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Glabellar rhytids in thyroid-associated orbitopathy
N D Saks1, M A Burnstine, A M Putterman
1Department of Ophthalmology, Advocate Medical Group, Park Ridge, Illinois, USA.
Ophthalmic Plastic and Reconstructive Surgery
|April 3, 2001
Summary
Glabellar rhytids are common in thyroid-associated orbitopathy (TAO). More severe wrinkles correlate with double vision (diplopia) and multiple disease signs in TAO patients.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- Thyroid-associated orbitopathy (TAO) is an autoimmune condition affecting the eye and surrounding tissues.
- Glabellar rhytids, or forehead wrinkles, are common cosmetic concerns.
Purpose of the Study:
- To investigate the correlation between the presence and severity of glabellar rhytids and the overall disease severity in patients diagnosed with TAO.
Main Methods:
- A retrospective review of 113 new patient visits for TAO.
- Ocular features like visual acuity, optic nerve status, proptosis, strabismus, and eyelid position were assessed.
- Glabellar rhytid severity was graded using clinical photographs and correlated with clinical findings using the Fisher exact test.
Main Results:
- Glabellar rhytids were observed in 82.5% of the 97 included patients.
- Eyelid retraction was nearly universal (98%).
- More severe rhytids were associated with diplopia (p < 0.05) and a higher number of abnormal clinical findings.
Conclusions:
- Glabellar rhytids are a frequent clinical sign in patients with TAO.
- The presence of glabellar rhytids, particularly more severe ones, may indicate a greater disease burden, including diplopia and multiple disease manifestations.