Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pain threshold is reduced in depression.

Donatella Marazziti1, Paolo Castrogiovanni, Alessandra Rossi

  • 1Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy.

The International Journal of Neuropsychopharmacology
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimized flow cytometry assay for functional characterization of variants of uncertain significance in familial hypercholesterolemia.

Atherosclerosis·2026
Same author

Multiparametric assessment of sarcopenia in systemic sclerosis: prognostic implications and interplay with malnutrition.

Clinical and experimental rheumatology·2026
Same author

Toward personalized persuasive social robots for behavior change in healthcare: a conceptual framework.

Frontiers in robotics and AI·2026
Same author

Predictive value of seizure onset for gross motor dysfunction in individuals with pathogenic GABRB2 and GABRB3 variants.

Epilepsia·2026
Same author

Measuring transparency in intelligent robots.

Scientific reports·2025
Same author

Early neurological symptoms and epilepsy outcomes in individuals with the recurrent GABRG2 p.(Ala106Thr) gain-of-function variant: Structural and phenotypic insights.

Epilepsia·2025

Depression patients exhibit higher pain and sensory thresholds compared to healthy individuals, suggesting altered neurochemical pathways. This finding may offer insights into the pathophysiology of depression and pain perception.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pain Research

Background:

  • Depression and pain share common neurochemical underpinnings.
  • Understanding pain sensation in depression aids in investigating depression's pathophysiology.

Purpose of the Study:

  • To investigate pain sensation in individuals with depression.
  • To compare pain and sensory thresholds between depressed patients and healthy controls.

Main Methods:

  • Utilized a dental tester to measure pain threshold.
  • Assessed sensory threshold in both depressed patients and healthy volunteers.

Main Results:

  • Depressed patients demonstrated a significantly higher sensory threshold.
  • A higher pain threshold was observed in patients compared to controls.

Related Experiment Videos

Conclusions:

  • Elevated thresholds in depression may indicate hyperfunction of the opiate system.
  • This could be linked to reduced modulation by neurotransmitters like serotonin.
  • Abnormalities in serotonin are well-documented in depressive states.