Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Knockout Corner.

Kimberly L. Stark1, René Hen

  • 1Columbia University, Center for Neurobiology and Behavior, 722 West 168th Street, New York, New York 10032.

The International Journal of Neuropsychopharmacology
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid solid-liquid optics enable scalable, high-resolution light-sheet microscopy across diverse immersion media.

Nature biotechnology·2026
Same author

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex.

bioRxiv : the preprint server for biology·2026
Same author

Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota.

NPJ biofilms and microbiomes·2026
Same author

Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Psilocybin induces sex- and context-specific recruitment of the stress axis.

Current biology : CB·2025
Same author

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy.

bioRxiv : the preprint server for biology·2025
Same journal

Genetic overlap between treatment-resistant schizophrenia and smoking initiation.

The international journal of neuropsychopharmacology·2026
Same journal

External Validation as the Critical Step for Predictive Biomarkers.

The international journal of neuropsychopharmacology·2026
Same journal

Viloxazine occupies the 5-HT2C receptor in the macaca fascicularis brain in vivo: A [11C]CIMBI-36 positron emission tomography study.

The international journal of neuropsychopharmacology·2026
Same journal

Divergent effects of interleukin-6 and ghrelin on remission and relapse in depression treatment.

The international journal of neuropsychopharmacology·2026
Same journal

Secondary Restless Legs Syndrome during psychopharmacological treatment: real-world evidence from a multinational pharmacovigilance program.

The international journal of neuropsychopharmacology·2026
Same journal

Recent cannabis exposure and acute nicotine effects: insights from randomized, double-blind, placebo-controlled intravenous nicotine studies.

The international journal of neuropsychopharmacology·2026
See all related articles

Mice lacking the serotonin 5-HT(1B) receptor gene offer insights into the serotonergic system. Analysis of these knockout mice reveals the receptor's role in complex behaviors, guiding future research directions.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Serotonin (5-hydroxytryptamine, 5-HT) is a crucial neurotransmitter regulating sleep, appetite, pain, and sexual activity.
  • Dysfunction in the serotonergic system is implicated in disorders like depression, anxiety, and migraine, with existing drugs targeting these pathways.
  • Serotonin exerts its effects via 14 known receptor subtypes, necessitating methods to study their individual contributions.

Purpose of the Study:

  • To investigate the role of specific serotonin receptor subtypes in complex behaviors.
  • To utilize gene targeting technology, specifically knockout mice, to understand receptor function.
  • To review findings on the serotonergic system and the 5-HT(1B) receptor using 5-HT(1B) receptor knockout mice.

Main Methods:

Related Experiment Videos

  • Employed a genetic approach using gene targeting to create knockout mice lacking specific serotonin receptor genes.
  • Analyzed the physiological and behavioral effects in mice lacking the gene for the 5-HT(1B) receptor.
  • Complemented traditional pharmacological studies with genetic models for studying serotonin receptor function.

    • Main Results:

    • The analysis of 5-HT(1B) receptor knockout mice has provided valuable information about the serotonergic system.
    • Specific findings regarding the function of the 5-HT(1B) receptor in complex behaviors have been elucidated through this genetic model.
    • This research highlights the utility of knockout mouse models in dissecting the roles of individual receptor subtypes.

    Conclusions:

    • 5-HT(1B) receptor knockout mice are instrumental in understanding the serotonergic system's role in behavior.
    • Findings from these studies have significant implications for understanding neurological and psychiatric disorders.
    • Future research will build upon these insights to further explore the serotonergic system's complexities.