Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Alpha4 integrins in cardiovascular development and diseases.

S Liu¹, D M Rose, J Han

¹Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Trends in Cardiovascular Medicine

|April 3, 2001

Summary

Alpha4 integrins directly bind to paxillin, a key interaction that regulates cell migration and focal adhesion. This binding is crucial for alpha4 integrin functions in cardiovascular development and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Initial results from the New Horizons exploration of 2014 MU<sub>69</sub>, a small Kuiper Belt object.

Science (New York, N.Y.)·2019

Same author

Associations of fatigue to work-related stress, mental and physical health in an employed community sample.

BMC psychiatry·2017

Same author

Focal femoral osteolysis after revision hip replacement with a cannulated, hydroxyapatite-coated long-stemmed femoral component: a new route for particulate wear debris.

The Journal of bone and joint surgery. British volume·2008

Same author

Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size.

Arteriosclerosis, thrombosis, and vascular biology·2006

Same author

Systemic irinotecan or regional floxuridine chemotherapy prolongs survival after hepatic cryosurgery in patients with metastatic colon cancer refractory to 5-fluorouracil.

Clinical colorectal cancer·2002

Same author

[Effect of Panax notoginseng saponin on Ca2+, CaM in craniocerebral injury].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2002

Area of Science:

Cell biology
Molecular biology
Cardiovascular research

Background:

Alpha4 integrins (alpha4beta1 and alpha4beta7) are critical for cardiovascular development and disease.
Alpha4 integrins regulate cell migration, spreading, and focal adhesion formation.

Purpose of the Study:

To review the knowns of the alpha4 integrin-paxillin interaction.
To discuss the regulatory mechanisms of this interaction in alpha4-mediated functions.

Main Methods:

Literature review of studies on alpha4 integrin and paxillin.
Analysis of the biological consequences of disrupting the alpha4-paxillin interaction.

Main Results:

Alpha4 integrin directly and tightly binds to the signaling adapter molecule paxillin.

Related Experiment Videos

Disruption of the alpha4-paxillin interaction impairs alpha4-dependent biological functions.

Conclusions:

The alpha4 integrin-paxillin interaction is essential for regulating alpha4-mediated cellular functions.
Understanding this interaction is key to understanding cardiovascular development and disease.