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Synthetic applications of epoxide hydrolases
1Groupe Biocatalyse et Chimie Fine, UMR CNRS 6111, Université de la Méditerranée, Faculté des Sciences de Luminy, Marseille, France. archelas@luminy.univ-mrs.fr
Current Opinion in Chemical Biology
|April 3, 2001
Abstract:
There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation of various epoxides and/or their corresponding diols in enantiopure form.