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Effects of sustained-release bupropion and supportive group therapy on cigarette consumption in patients with
E Weiner1, M P Ball, A Summerfelt
1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, P.O. Box 21247, Baltimore, MD 21228, USA. eweiner@mprc.umaryland.edu
Objective:
The study examined the efficacy, tolerability, and safety of supportive group psychotherapy and adjunctive sustained-release bupropion for nicotine addiction in patients with schizophrenia.
Method:
Eight patients participated in a 14-week open-label trial. End expired breath carbon monoxide level, symptom levels, neuropsychological performance, and suppression of the P50 event-related potential were measured before and after the 14-week trial.
Results:
Patients showed a decrease in carbon monoxide levels that was not associated with any worsening in symptom, neuropsychological, or P50 suppression measures.
Conclusions:
Use of sustained-release bupropion in combination with supportive group therapy may help patients with schizophrenia decrease their cigarette consumption.