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Related Experiment Videos

Anitschkow nuclear changes in postmortem pericardial scrapings.

C P Molina1, V J Schnadig

  • 1Division of Cytopathology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0548, USA.

Acta Cytologica
|April 4, 2001
PubMed
Summary
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Anitschkow nuclear changes (ANC) were identified in pericardial mesothelial cells during postmortem cytology. These nuclear changes were clearly visible in scrapings, suggesting they are a nonspecific reactive cellular alteration.

Area of Science:

  • Cardiovascular Pathology
  • Cytopathology
  • Autopsy Science

Background:

  • Anitschkow nuclear changes (ANC) are typically observed in cardiomyocytes.
  • Their presence in pericardial mesothelium at autopsy is not well-documented.

Purpose of the Study:

  • To investigate the occurrence of ANC in pericardial mesothelial cells.
  • To evaluate the utility of postmortem pericardial scrapings for identifying ANC.

Main Methods:

  • Cytologic examination of pericardial scrapings from 14 autopsy cases.
  • Papanicolaou staining and evaluation for ANC.
  • Histologic correlation was performed.

Main Results:

  • ANC were identified in pericardial mesothelial cells in 6 out of 14 cases.

Related Experiment Videos

  • ANC were more readily visualized in cytologic preparations than in histologic sections.
  • Associated causes of death included sepsis, cardiac arrhythmia, lymphoma, and hepatic necrosis.

    • Conclusions:

    • Postmortem pericardial cytology is a valuable tool for identifying ANC.
    • ANC in pericardial mesothelium appear to be a nonspecific reactive change.
    • Findings support the theory of ANC as a reactive cellular alteration.