Related Experiment Videos
The effect of systemic hypertension on pulsatile ocular blood flow in diabetic patients
1Ophthalmology Clinic of Trakya University Medical Faculty, Edirne, Turkey. mmelodi@ttnet.net.tr
Insights
Pulsatile ocular blood flow is reduced in diabetics without hypertension. Systemic hypertension may preserve choroidal blood flow in diabetic patients, indicating its potential impact on ocular hemodynamics.
Area of Science:
- Ophthalmology
- Diabetology
- Cardiovascular Science
Background:
- Diabetes mellitus is a systemic disease affecting ocular vasculature.
- Understanding the hemodynamics of the ciliary choroidal system is crucial for managing diabetic eye complications.
Purpose of the Study:
- To investigate the haemodynamics of the ciliary choroidal system in diabetic patients.
- To assess the influence of systemic hypertension on ocular blood flow in diabetes.
Main Methods:
- Analysis of pulsatile ocular blood flow (POBF) using an ocular blood flow tonograph.
- Inclusion of 90 eyes from 45 diabetic patients, categorized by hypertension status.
- Comparison with a control group of 20 healthy volunteers.
Main Results:
- Diabetics without hypertension showed significantly lower pulse amplitude (PA), pulse volume (PV), and POBF compared to controls (p<0.05).
- Diabetic patients with hypertension did not exhibit significant differences in PA, PV, or POBF compared to controls, despite elevated blood pressure.
Conclusions:
- POBF is diminished in diabetic individuals without systemic hypertension.
- Systemic hypertension might play a protective role in maintaining choroidal blood flow in diabetic patients.
Purpose:
To determine the haemodynamics of the ciliary choroidal system in diabetics with or without systemic hypertension.
Methods:
90 eyes of 45 diabetic patients were included into the study. Patients were divided into two groups based on the presence of systemic hypertension. The pulsatile component of the total ocular blood flow in diabetics with or without hypertension was analyzed using ocular blood flow tonograph (OBF Labs, UK). The control group was comprised of 40 age-matched eyes of 20 volunteers with no ocular or systemic disease. Results were compared with the control group.
Results:
Pulse amplitude (PA), pulse volume (PV) and pulsatile ocular blood flow (POBF) were significantly lower (p<0.05) in diabetics without systemic hypertension than the controls. In diabetics with hypertension, although the systolic and diastolic blood pressures were significantly higher than the control group, there was not any statistically significant difference (p>0.05) between PA, PV and POBF results.
Conclusion:
POBF was found to be lower in diabetics without hypertension compared to the controls. Such a presence of systemic hypertension may increase the choroidal blood flow in diabetics.