Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Matrix metalloproteinases and bladder cancer.

¹Department of Urology, The University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.

The Journal of Medical Investigation : JMI

|April 5, 2001

Summary

Matrix metalloproteinases (MMPs) are key enzymes in cancer progression. This review discusses their roles and clinical significance in bladder cancer, highlighting their association with tumor advancement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of C-reactive protein with efficacy of avelumab plus axitinib in advanced renal cell carcinoma: long-term follow-up results from JAVELIN Renal 101.

ESMO open·2022

Same author

Role of rBAT gene products in cystinuria.

International journal of urology : official journal of the Japanese Urological Association·2014

Same author

Comparison of efficacy of pitavastatin and colestimide in Japanese patients with diabetes mellitus complicated by hyperlipidemia and metabolic syndrome.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2011

Same author

Enhancement of osteoclastogenic activity in osteolytic prostate cancer cells by physical contact with osteoblasts.

British journal of cancer·2011

Same author

The incidence and mechanism of sunitinib-induced thyroid atrophy in patients with metastatic renal cell carcinoma.

British journal of cancer·2010

Same author

Comparative study of low-dose pioglitazone or metformin treatment in Japanese diabetic patients with metabolic syndrome.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2009

Area of Science:

Oncology
Biochemistry

Background:

Matrix metalloproteinases (MMPs) are enzymes degrading extracellular matrix, crucial for tumor invasion and metastasis.
Elevated MMP-2 and MMP-9 expression is linked to bladder cancer stage, grade, and prognosis.
Increased serum/urine MMPs and TIMPs are observed in bladder cancer patients, particularly in advanced stages.

Purpose of the Study:

To discuss the roles of MMPs in bladder cancer progression.
To explore the clinical implications of MMPs in bladder cancer.

Main Methods:

Literature review of studies on MMPs and TIMPs in bladder cancer.
Analysis of correlations between MMP expression and clinical parameters.
Discussion of existing research on MMPs' functions in bladder cancer.

Main Results:

MMPs play essential roles in tumor invasion and metastasis.
MMP-2 and MMP-9 expression correlates with bladder cancer stage, grade, and prognosis.
Elevated MMPs and TIMPs in bodily fluids suggest a link to advanced bladder cancer.

Conclusions:

MMPs are significantly involved in bladder cancer progression.
Further research is needed to clarify the precise roles and clinical utility of MMPs and TIMPs in bladder cancer.
Understanding MMPs' functions may lead to improved diagnostic and therapeutic strategies for bladder cancer.

Related Experiment Videos