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Updated: Aug 17, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Structured treatment interruptions to control HIV-1 and limit drug exposure
1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Montaner@wistar.upenn.edu
Abstract:
Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-mediated control of HIV-1. Such an approach has the ultimate objective of harnessing anti-viral immune responses, reducing drug exposure (toxicity and cost) and potentially extending the clinical benefits of a suppressive treatment regimen.
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