Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human memory T cells: lessons from stem cell transplantation.

N Rufer1, C Helg, B Chapuis

  • 1Division of Immunology and Allergology, University Hospital of Geneva, 24 rue Micheli-du-Crest, CH-1211 14, Genève, Switzerland.

Trends in Immunology
|April 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human pegivirus persistence in human blood virome after allogeneic haematopoietic stem-cell transplantation.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same author

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

Translational research : the journal of laboratory and clinical medicine·2017
Same author

Outcome of hematopoietic stem cell transplantation is similar for patients with a partial in vitro T-cell-depleted graft compared with a non-T-cell-depleted graft when stratified by the refined disease risk index.

Bone marrow transplantation·2016
Same author

Excellent outcome with a high proportion of mixed chimerism in patients with severe aplastic anemia treated with partially T-cell-depleted peripheral hematopoietic stem cell transplants.

Bone marrow transplantation·2016
Same author

Torque teno virus in patients undergoing allogeneic hematopoietic stem cell transplantation for hematological malignancies.

Bone marrow transplantation·2015
Same author

The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantation.

Leukemia·2012

Human memory T cells, crucial for immunity, remain poorly understood. This study in stem-cell-transplanted patients offers new insights into the human T-cell compartment and memory T-cell dynamics.

Area of Science:

  • Immunology
  • Hematology
  • Cellular Biology

Background:

  • Animal models elucidate T-cell pool organization, but human memory T cells are less understood.
  • Memory T cells exhibit variable lifespans and antigen encounter histories.
  • Understanding human T-cell memory is critical for adaptive immunity and vaccine development.

Purpose of the Study:

  • To investigate the organization and dynamics of the human T-cell compartment.
  • To gain insights into memory T-cell populations in a human context.
  • To explore T-cell memory formation and maintenance post-hematopoietic stem cell transplantation.

Main Methods:

  • Analysis of T-cell populations in patients undergoing hematopoietic stem cell transplantation.
  • Longitudinal monitoring of T-cell repertoire diversity and phenotype.

Related Experiment Videos

  • Assessment of T-cell responses to recall antigens.

    • Main Results:

    • Characterization of distinct human memory T-cell subsets with varying lifespans.
    • Demonstration of T-cell repertoire reconstitution following stem cell transplantation.
    • Identification of factors influencing memory T-cell persistence and function.

    Conclusions:

    • Stem cell transplantation provides a unique model to study human T-cell memory.
    • Human T-cell memory is shaped by complex interactions and antigen exposure.
    • Findings contribute to a deeper understanding of adaptive immunity in humans.