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Possible modes of action of the artemisinin-type compounds
P L Olliaro1, R K Haynes, B Meunier
1UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases, CDS Cluster, 20, avenue Appia, CH-1211, Geneva, Switzerland. olliarop@who.ch
Trends in Parasitology
|April 5, 2001
Abstract:
Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.