Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytotoxic T cells and mycobacteria.

C L Silva1, V L Bonato, K M Lima

  • 1Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. clsilva@fmrp.usp.br

FEMS Microbiology Letters
|April 5, 2001
PubMed
Summary

The immune system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential cost-effectiveness of outdoor unhealthy food and drink advertising restrictions in Western Australia.

Public health nutrition·2026
Same author

Erratum: Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 116, 122301 (2016)].

Physical review letters·2025
Same author

Disentangling Centrality Bias and Final-State Effects in the Production of High-p_{T} Neutral Pions Using Direct Photon in d+Au Collisions at sqrt[s_{NN}]=200  GeV.

Physical review letters·2025
Same author

On the origin of low-valent uranium oxidation state.

Nature communications·2024
Same author

Predicting response to neoadjuvant chemotherapy with liquid biopsies and multiparametric MRI in patients with breast cancer.

NPJ breast cancer·2024
Same author

Nationwide analysis of open groin hernia repairs in Italy from 2015 to 2020.

Hernia : the journal of hernias and abdominal wall surgery·2023

Area of Science:

  • Immunology
  • Microbiology
  • Vaccinology

Background:

  • The precise mechanisms by which the immune system combats Mycobacterium tuberculosis remain incompletely understood.
  • Classical models emphasize the role of activated macrophages in phagocytosing and eliminating the bacteria.

Purpose of the Study:

  • To investigate the contribution of cytotoxic T lymphocytes to Mycobacterium tuberculosis clearance.
  • To explore the potential of DNA vaccines in augmenting anti-tuberculosis immunity.

Main Methods:

  • Review of recent immunological evidence.
  • Conceptual analysis of immune effector mechanisms against Mycobacterium tuberculosis.

Main Results:

  • Evidence suggests that cytotoxic T lymphocytes play a significant role in controlling Mycobacterium tuberculosis infection.
  • Phagocytosis by macrophages may not be the sole or primary mechanism of bacterial killing.

Conclusions:

  • Cytotoxic T lymphocytes are a crucial component of the immune response to Mycobacterium tuberculosis.
  • DNA vaccination strategies hold promise for enhancing cell-mediated immunity against tuberculosis.

Related Experiment Videos