Related Experiment Video
Updated: Jul 19, 2026
12:22
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Crossed cerebellar diaschisis in herpes simplex encephalitis.
1Department of Neurology, Mackay Memorial Hospital, 92 Section 2 Chung-Shan North Road, P.O. Box Nei-hu 6-30, Taipei, Taiwan. thajebp@hotmail.com
European Journal of Radiology
|April 5, 2001
Summary
Crossed cerebellar diaschisis (CCD) is a rare complication of viral encephalitis. This case report details CCD in a patient with herpes simplex type-1 (HSV-1) encephalitis, confirmed via cerebrospinal fluid analysis.
Area of Science:
- Neurology
- Neurovirology
- Neuroradiology
Background:
- Crossed cerebellar diaschisis (CCD) is an uncommon neurological phenomenon.
- Viral encephalitis, particularly herpes simplex type-1 (HSV-1), can present with diverse neurological complications.
Observation:
- A 73-year-old male diagnosed with acute HSV-1 encephalitis.
- Cerebrospinal fluid (CSF) analysis confirmed HSV-1 deoxyribonucleic acid.
- Magnetic resonance imaging (MRI) revealed enhancing lesions in bilateral temporal lobes, insular cortices, and right frontoparietal lobes, with increased T2 signal intensity in the mesencephalon.
Findings:
- Technetium-99m ethyl cysteinate dimer (99mTc-ECD) single photon emission computed tomography (SPECT) demonstrated significant hypoperfusion in the right frontotemporoparietal lobes.
- A 19% reduction in radioisotope tracer uptake was observed in the left cerebellum, indicative of CCD.
- The proposed mechanism involves disruption of corticopontocerebellar tracts and dentatothalamocortical projections.
Implications:
- This case highlights the potential for CCD in HSV-1 encephalitis, expanding the known spectrum of this rare condition.
- Understanding the neuroanatomical basis of diaschisis in viral encephalitis is crucial for accurate diagnosis and patient management.
- Further research into the pathophysiology of diaschisis in infectious neurological diseases is warranted.
More Related Videos
05:51Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
08:41Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice
Published on: December 29, 2016
Related Concept Videos
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...