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Emerging protein delivery methods
J L Cleland1, A Daugherty, R Mrsny
1Pharmaceutical Research & Development, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. cleland@gene.com
Current Opinion in Biotechnology
|April 5, 2001
Summary
Evaluating protein delivery methods is crucial for biotechnology products. Injection devices, depot systems, and pulmonary administration are currently the most viable commercial options.
Area of Science:
- Biotechnology
- Drug Delivery Systems
- Pharmaceutical Sciences
Background:
- Efficient and safe delivery of therapeutic proteins is critical for the success and efficacy of biotechnology products.
- Numerous protein delivery technologies have emerged, necessitating a critical evaluation of their manufacturing, impact on protein quality, bioavailability, and toxicity.
Purpose of the Study:
- To critically assess various protein delivery technologies for commercial viability.
- To identify the most promising protein delivery routes for future biotechnology products.
Main Methods:
- Evaluation of protein delivery methods based on manufacturing ease, protein quality impact, bioavailability, and toxicity.
- Comparative analysis of depot, pulmonary, transdermal, and oral delivery systems.
Main Results:
- Depot delivery systems largely overcome obstacles but face manufacturing challenges.
- Pulmonary delivery offers efficient manufacturing but suffers from low bioavailability, requiring higher doses.
- Transdermal and oral delivery show promise but need significant bioavailability improvements for commercialization.
Conclusions:
- Injection devices, depot systems, and pulmonary administration are the most likely protein delivery methods for commercial products in the near future.
- Further advancements in bioavailability are needed for transdermal and oral protein delivery to become commercially viable.