Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging protein delivery methods.

J L Cleland1, A Daugherty, R Mrsny

  • 1Pharmaceutical Research & Development, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. cleland@gene.com

Current Opinion in Biotechnology
|April 5, 2001
PubMed
Summary

Evaluating protein delivery methods is crucial for biotechnology products. Injection devices, depot systems, and pulmonary administration are currently the most viable commercial options.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation.

Circulation·2005
Same author

Paradoxical reduction of atherosclerosis in apoE-deficient mice with obesity-related type 2 diabetes.

Cardiovascular research·2003
Same author

A slow release formulation of insulin as a treatment for osteoarthritis.

Osteoarthritis and cartilage·2002
Same author

Encapsulation and stabilization of nerve growth factor into poly(lactic-co-glycolic) acid microspheres.

Journal of pharmaceutical sciences·2001
Same author

Comparison of the rates of deamidation, diketopiperazine formation and oxidation in recombinant human vascular endothelial growth factor and model peptides.

AAPS pharmSci·2001
Same author

Comparison between light induced and chemically induced oxidation of rhVEGF.

Pharmaceutical research·2001

Area of Science:

  • Biotechnology
  • Drug Delivery Systems
  • Pharmaceutical Sciences

Background:

  • Efficient and safe delivery of therapeutic proteins is critical for the success and efficacy of biotechnology products.
  • Numerous protein delivery technologies have emerged, necessitating a critical evaluation of their manufacturing, impact on protein quality, bioavailability, and toxicity.

Purpose of the Study:

  • To critically assess various protein delivery technologies for commercial viability.
  • To identify the most promising protein delivery routes for future biotechnology products.

Main Methods:

  • Evaluation of protein delivery methods based on manufacturing ease, protein quality impact, bioavailability, and toxicity.
  • Comparative analysis of depot, pulmonary, transdermal, and oral delivery systems.

Main Results:

  • Depot delivery systems largely overcome obstacles but face manufacturing challenges.
  • Pulmonary delivery offers efficient manufacturing but suffers from low bioavailability, requiring higher doses.
  • Transdermal and oral delivery show promise but need significant bioavailability improvements for commercialization.

Conclusions:

  • Injection devices, depot systems, and pulmonary administration are the most likely protein delivery methods for commercial products in the near future.
  • Further advancements in bioavailability are needed for transdermal and oral protein delivery to become commercially viable.

Related Experiment Videos