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Identification of co-mutagenic chlorinated harmans in final effluent from a sewage treatment plant
H Fukazawa1, H Matsushita, Y Terao
1Institute for Environmental Sciences, University of Shizuoka, 52-1 Yada, 422-8526, Shizuoka, Japan.
Mutation Research
|April 5, 2001
Abstract:
Harman (1-methyl-9H-pyrido[3,4-b]indole) reacted readily with sodium hypochlorite in an aqueous medium to give the mono-chlorinated derivatives, which reportedly have greater co-mutagenic activity than harman in the presence of o-toluidine toward Salmonella typhimurium TA 98 with S9 mix. Mono-chlorinated harmans were detected by concentration using blue rayon (BR) and GC/MS analysis in the final effluent from a sewage treatment plant in Shizuoka, Japan. The amounts adsorbed for 24h were 1-45ng/gBR for mono-chlorinated harman and 110-730ng/gBR for harman.