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Related Experiment Videos

A study of tremor in multiple sclerosis.

S H Alusi1, J Worthington, S Glickman

  • 1Department of Neurosciences, Charing Cross Hospital, Imperial College School of Medicine, London, UK.

Brain : a Journal of Neurology
|April 5, 2001
PubMed
Summary

Tremor affects over half of multiple sclerosis patients, primarily as action tremor in the arms. This tremor correlates with disability and other neurological symptoms, impacting daily life for many.

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Area of Science:

  • Neurology
  • Clinical Medicine
  • Neuroscience

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Tremor is a common but often understudied symptom in MS patients.
  • Understanding tremor's characteristics is crucial for managing MS-related disability.

Purpose of the Study:

  • To investigate the prevalence, subtypes, clinical features, and disability associated with tremor in multiple sclerosis.
  • To characterize the types and severity of tremor in an MS population.
  • To explore the relationship between tremor and disability in multiple sclerosis.

Main Methods:

  • A study of 100 randomly selected patients with definite multiple sclerosis.
  • Assessment of tremor prevalence, type (postural, kinetic, intention), severity, and affected body parts.
  • Correlation analysis of tremor with disability scores (Expanded Disability Systems Score, Barthel indices) and neurological signs (dysarthria, dysmetria).

Main Results:

  • Tremor was detected in 58% of patients, predominantly as action tremor in the arms.
  • Tremor severity correlated with dysarthria, dysmetria, and dysdiadochokinesia.
  • Twenty-seven percent experienced tremor-related disability, with 10% having incapacitating tremor, and a higher likelihood of wheelchair dependence in those with abnormal tremor.

Conclusions:

  • Tremor is a highly prevalent and disabling symptom in multiple sclerosis.
  • Action tremor, particularly in the upper limbs, is the most common type.
  • Tremor significantly contributes to disability and reduced quality of life in MS patients.

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