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Related Experiment Videos

HIV associated nephropathy: a treatable condition.

M G Brook1, R F Miller

  • 1Patrick Clements Clinic, Department of GUM/HIV, Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK. gary.brook@cmh-tr.nthames.nhs.uk

Sexually Transmitted Infections
|April 5, 2001
PubMed
Summary

HIV-associated nephropathy (HIVAN) is a significant kidney disease in HIV patients, particularly those of African descent. Early detection and treatment with highly active antiretroviral therapy (HAART) can dramatically improve renal function, making HIVAN a treatable condition.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • HIV-associated nephropathy (HIVAN) is a frequent complication in Black African and Afro-Caribbean patients with HIV.
  • HIVAN presents as progressive renal failure and significant proteinuria.

Purpose of the Study:

  • To review current knowledge on the causes, pathology, diagnosis, and treatment of HIVAN.
  • To highlight the increasing importance of HIVAN as HIV-infected patients receive effective antiretroviral therapy.

Main Methods:

  • Conducted a Medline search using keywords: HIV, nephropathy, renal, kidney.
  • Performed additional searches on antiretroviral agents, renal/kidney terms, and MeSH heading "pharmacokinetics".

Main Results:

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  • HIVAN is a common cause of renal impairment in HIV-infected individuals, especially certain ethnic groups.
  • Highly active antiretroviral therapy (HAART) is associated with significant improvement in renal function for HIVAN patients.
  • As other renal failure causes decrease with HAART, HIVAN is expected to become more prominent.

    • Conclusions:

    • HIV-associated nephropathy is a treatable renal condition.
    • Active screening for HIVAN in HIV-infected patients is crucial for therapeutic benefit.