Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis and pathology of COPD.

G Turato1, R Zuin, M Saetta

  • 1Dipartimento di Medicina Clinica e Sperimentale, Sezione di Malattie dell'Apparato Respiratorio, e Università degli Studi di Padova, Padova, Italia.

Respiration; International Review of Thoracic Diseases
|April 5, 2001
PubMed
Summary

Chronic obstructive pulmonary disease (COPD) involves airflow limitation due to increased airway resistance and reduced lung elastic recoil. This review details structural changes in airways and lung tissue contributing to COPD

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biopsy techniques : optimization for collection and preservation.

Methods in molecular medicine·2011
Same author

Noneosinophilic asthma in children: relation with airway remodelling.

The European respiratory journal·2011
Same author

Hepatic Clearance and Lm of Galactose in Normal and Cirrhotic Subjects.

Postgraduate medical journal·2011
Same author

Markers of eosinophilic and neutrophilic inflammation in bronchoalveolar lavage of asthmatic and atopic children.

Allergy·2009
Same author

Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment.

Thorax·2009
Same author

Overexpression of squamous cell carcinoma antigen in idiopathic pulmonary fibrosis: clinicopathological correlations.

Thorax·2008

Area of Science:

  • Pulmonary Medicine
  • Respiratory System Pathophysiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is defined by airflow limitation.
  • Airflow limitation arises from increased airway resistance and decreased lung elastic recoil.
  • Both peripheral and central airways, along with lung parenchyma, are implicated in COPD.

Purpose of the Study:

  • To review structural and cellular changes in COPD patients.
  • To examine changes in peripheral airways, central airways, and lung parenchyma.
  • To identify mechanisms contributing to airflow limitation in COPD.

Main Methods:

  • Review of existing literature on COPD structural and cellular changes.
  • Analysis of studies focusing on peripheral airways, central airways, and lung parenchyma.

Related Experiment Videos

  • Synthesis of data on mechanisms of airflow limitation.

    • Main Results:

    • Increased resistance from airway obstruction is a key factor in COPD.
    • Loss of lung elastic recoil due to parenchymal destruction contributes significantly.
    • Both central and peripheral airways exhibit structural and cellular alterations in COPD.

    Conclusions:

    • COPD pathophysiology involves complex changes across the respiratory system.
    • Understanding these structural and cellular changes is crucial for addressing airflow limitation.
    • Further research into the mechanisms driving these changes may reveal new therapeutic targets.