Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A selenide linker for "traceless" solid-phase organic synthesis.

Z Li1, B A Kulkarni, A Ganesan

  • 1Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609, Singapore.

Biotechnology and Bioengineering
|April 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein domain movement involved in binding of belinostat and HPOB as inhibitors of histone deacetylase 6 (HDAC6): a hybrid automated-interactive docking study.

Journal of computer-aided molecular design·2025
Same author

Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of <i>Schistosoma mansoni</i>.

ACS infectious diseases·2025
Same author

Synthesis of a Trans-Phakellistatin 21/22 Conformer and Related Alanine Scanning Analogs With Neuroprotective Activity.

Journal of peptide science : an official publication of the European Peptide Society·2025
Same author

The cytochalasans: potent fungal natural products with application from bench to bedside.

Natural product reports·2025
Same author

Evaluation of the Recent Dynamics for Funding Medicinal Chemistry Projects in Academia. Results of a Survey Conducted by IUPAC Division VII (Chemistry and Human Health).

Journal of medicinal chemistry·2025
Same author

Phytochemicals in Drug Discovery-A Confluence of Tradition and Innovation.

International journal of molecular sciences·2024

Researchers developed a novel polymer-bound selenide anion linker. This traceless linker facilitates reactions with electrophiles, offering a new tool in synthetic chemistry.

Area of Science:

  • Organic Chemistry
  • Polymer Chemistry
  • Synthetic Methodology

Background:

  • Solid-phase synthesis is crucial for efficient chemical library generation.
  • Developing novel linkers can improve the versatility and efficiency of solid-phase reactions.
  • Selenium-containing compounds offer unique reactivity in organic synthesis.

Purpose of the Study:

  • To synthesize and characterize a novel polymer-bound selenide anion.
  • To evaluate the utility of this selenide anion as a traceless linker for solid-phase synthesis.
  • To demonstrate its application in reactions with various electrophiles.

Main Methods:

  • Protection of 4-bromophenethyl alcohol as a tetrahydropyranyl (THP) ether.
  • Formation of the diselenide via reaction with magnesium and selenium.

Related Experiment Videos

  • Attachment of the diselenide diol to solid-phase resins.
  • Generation of the polymer-bound selenide anion.

    • Main Results:

    • Successful synthesis of the polymer-bound selenide anion.
    • Demonstration of the selenide anion as an effective traceless linker.
    • Successful attachment of electrophiles, such as alkyl halides, to the resin via the linker.
    • The linker is removed under specific conditions, leaving the desired product.

    Conclusions:

    • The developed polymer-bound selenide anion serves as a versatile and traceless linker.
    • This methodology expands the toolkit for solid-phase synthesis.
    • It enables efficient functionalization of solid supports with electrophiles.