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Related Experiment Videos

A sol-gel derived bioactive fibrous mesh.

R Z Domingues1, A E Clark, A B Brennan

  • 1Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627-Belo Horizonte-MG-CEP 31270-901, Brazil.

Journal of Biomedical Materials Research
|April 5, 2001
PubMed
Summary

Bioactive fiber sheets were created using sol-gel and spray processes. These novel materials show excellent chemical stability and potential as scaffolds for tissue regeneration.

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Tissue Engineering

Background:

  • Developing bioactive materials for tissue regeneration is crucial.
  • Nonwoven scaffolds offer unique properties for cellular interaction.
  • Sol-gel and spray processes enable precise control over material synthesis.

Purpose of the Study:

  • To produce nonwoven sheets of bioactive fibers using a sol-gel and high-velocity spray process.
  • To investigate the bioactivity and chemical stability of SiO(2)-CaO-P(2)O(5) fibers.
  • To evaluate the potential of these fibers as scaffolds for tissue engineering.

Main Methods:

  • Sol-gel synthesis followed by high-velocity spray deposition to create nonwoven fiber sheets.
  • Characterization of fiber compositions within the SiO(2)-CaO-P(2)O(5) system.

Related Experiment Videos

  • Assessment of bioactivity via hydroxy carbonate apatite (HCA) formation in simulated body fluid (SBF) and analysis using DRIFTS and SEM.

    • Main Results:

    • Homogeneous HCA layer formation on fibers within 3 hours of SBF immersion, confirming bioactivity.
    • Higher HCA concentration observed in silica-rich fiber compositions.
    • Bioactive fiber sheets demonstrated superior chemical stability compared to powders and monoliths.

    Conclusions:

    • The sol-gel and spray process successfully produced chemically stable bioactive fiber sheets.
    • These materials exhibit promising bioactivity, indicated by rapid HCA formation.
    • The developed fiber sheets are suitable for potential applications as scaffolds in both mineralized and non-mineralized tissue engineering.