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Updated: Oct 8, 2026

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Published on: February 4, 2015
Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy
R J Wapner1, T M Jenkins, N Silverman
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107-5083, USA.
Abstract:
The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.
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