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Related Experiment Videos

Laboratory studies with some recent anticoccidials.

J F Ryley, R G Wilson

    Parasitology
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Lasalocid and halofuginone effectively controlled Eimeria infections in chicks, unlike monensin. These anticoccidial drugs inhibit early parasite development and have rapid lethal effects, though lab results may differ in field performance.

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    Area of Science:

    • Veterinary Parasitology
    • Poultry Science
    • Pharmacology

    Background:

    • Coccidiosis, caused by Eimeria species, is a significant disease in poultry.
    • Anticoccidial drugs are crucial for managing Eimeria infections in commercial chicken flocks.
    • Monensin, lasalocid, and halofuginone are ionophore and non-ionophore anticoccidials with varying efficacy.

    Purpose of the Study:

    • To evaluate the efficacy of monensin, lasalocid, and halofuginone against key Eimeria species in chickens.
    • To determine if complete control of experimental infections, separate from toxicity, could be achieved.
    • To compare the early life-cycle inhibition and lethal effects of these anticoccidial compounds.

    Main Methods:

    • Laboratory studies assessing drug activity against Eimeria tenella, E. brunetti, and E. necatrix.

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  • In vivo experiments in chicks to evaluate efficacy and toxicity.
  • In vitro studies to supplement in vivo observations.
  • Dosage levels tested were 150 ppm for lasalocid and 6 ppm for halofuginone.

    • Main Results:

    • Lasalocid and halofuginone achieved complete control of experimental Eimeria infections without discernible toxicity.
    • Monensin did not provide complete control of infections under the tested laboratory conditions.
    • All three compounds demonstrated early inhibition of coccidial development and rapid lethal effects, with monensin and lasalocid being more potent than halofuginone.

    Conclusions:

    • Lasalocid and halofuginone are effective anticoccidial agents for controlling Eimeria infections in poultry.
    • The study highlights the importance of differentiating drug efficacy from toxicity in anticoccidial drug evaluation.
    • Challenges exist in directly correlating laboratory findings with real-world field performance of anticoccidial treatments.