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Related Experiment Videos

Extraskeletal osteosarcoma arising in myositis ossificans.

E Konishi1, K Kusuzaki, H Murata

  • 1Department of Pathology, Kyoto Prefectural University of Medicine, Japan.

Skeletal Radiology
|April 6, 2001
PubMed
Summary

This case report details an extremely rare instance of extraskeletal osteosarcoma developing from myositis ossificans in a woman's wrist. The study highlights the malignant transformation of a benign soft tissue bony mass.

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Area of Science:

  • Orthopedic Oncology
  • Soft Tissue Tumors
  • Bone Pathology

Background:

  • Extraskeletal osteosarcoma is a rare malignant bone tumor arising outside the periosteum.
  • Myositis ossificans is a benign, non-neoplastic condition characterized by heterotopic ossification in soft tissues.

Observation:

  • A 53-year-old woman presented with a 4-year history of a soft tissue bony mass on her left wrist.
  • The mass initially was soft and mobile, becoming hard and fixed within the first year.
  • Radiological imaging revealed features of mature myositis ossificans with "eggshell" ossification.

Findings:

  • Histological examination showed a high-grade osteosarcoma between the radius and the bony shell of the myositis ossificans.
  • A nonmineralized soft tissue mass was noted between the radius surface and the bony shell.

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  • The findings indicated malignant transformation of myositis ossificans into extraskeletal osteosarcoma.

    • Implications:

    • This case underscores the potential for malignant transformation in long-standing myositis ossificans.
    • It emphasizes the importance of thorough histopathological evaluation for soft tissue masses with ossification.
    • Further research is needed to understand the mechanisms and risk factors for this rare transformation.