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Updated: Aug 14, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Translocation of a confined polymer through a hole
1Department of Polymer Science and Engineering, and Materials Research Science and Engineering Center, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Abstract:
Based on an analogy between polymer translocation across a free energy barrier associated with polymer worming through a hole and classical nucleation and growth process, the escape time tau is predicted asymptotically to be N(N/rho)(1/3nu). N is the polymer length, rho is the monomer density prior to escape, and nu is the radius of gyration exponent. Monte Carlo simulation data collected in the high salt limit (nu approximately 3/5) are in agreement with the asymptotic law and provide vivid details of the escape.
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